Showing posts with label Medical News. Show all posts
Showing posts with label Medical News. Show all posts

Tuesday, October 11, 2011

How Long Does Pneumonia Last ?

Pneumonia causes respiratory illness & infects the lungs. The lungs get inflamed, & they get filled with extra fluid. This leads infection, which is caused by bacteria, virus, fungi or parasites. The lungs are the most affected parts when someone gets infected with pneumonia.

After a person is said to have pneumonia, he will be prescribed with antibiotics, anti-fungal medications & antiviral medications, depending on the cause of the disease. Walking pneumonia is a kind of mild pneumonia. If the severity is high, it is called double pneumonia. In case the severity is high, hospitalization is required with oxygen & strong medication.

If the patient does not have any other illness, he can recover in 2 weeks after being diagnosed with pneumonia. People who have asthma, respiratory disorders & smokers will take many weeks or months to recover. Even after the infection is cured, cough will remain for some more weeks. The people who are old need to be cared for a lot in case they are infected with pneumonia. Seniors & children are high risk categories.

To recover faster, you can take a few measures though. Take adequate rest, drink lots of fluids, use the medicines as prescribed, & take steamy showers to clear the lungs. Also, inhale hot steam from fluids, & get out the excess mucus when you cough. Doctors will prescribe medicines to make the mucus thin in the lungs to help you overcome the infection. You can use over the counter drugs to reduce the cough, but it is better to consult your doctor before you use these drugs or any herbal medicines.

More about Pneumocystis pneumonia (PCP) and HIV

What Is Pcp?

Pneumonia is an infection that inflames your lungs' air sacs. The air sacs may fill
up with fluid or pus, causing symptoms such as a cough with phlegm, fever, ...


PCP is a kind of pneumonia caused by Pneumocystis jiroveci (P. jiroveci). (Say the name this way: "new-mo-sis-tis yee-row-vet-zee-eye.") It used to be called Pneumocystis cariniipneumonia. Most people infected with P. jirovecidon't get pneumonia because their immune systems are healthy and strong. People whose immune systems are weak because of HIV infection can get PCP. PCP is less common than it used to be, but it's still the most common serious infection in people with advanced HIV disease in the United States.
How Would I Know If I Have Pcp?

If you get PCP, you probably will have fever, cough, trouble breathing (especially with exercise) or chest tightness. See your doctor right away if you have these symptoms. Most cases are mild, but people with severe PCP may die if the infection isn't treated quickly. PCP is diagnosed by lab tests of fluid or tissue from your lungs.
How Do You Get Pcp?

Most scientists believe PCP is spread in the air, but they don't know if it lives in the soil or someplace else. P. jiroveciis common all over the world. Since you can't help being exposed to P. jiroveci, you should get medical care so you won't get PCP. (PCP is not spread by sex.)

Biggest baby killer in Bangladesh [ Pneumonia ]

Pneumonia is the biggest baby killer in Bangladesh, but most of the people do not realise its all-pervasive presence, say health experts.

Widespread malnutrition & poor hygiene have been blamed for the 'dangerous' lung disease that, according to ministry of health, accounts for 18 percent of deaths under five.

"It (Pneumonia) can put pressure on achieving Millennium Development Goal 4," paediatrician Prof Ruhul Amin of Dhaka Shishu Hospital told a journalists' workshop in the capital.

The workshop organised by non-government organisation Poriprekkhit suggested awareness campaign on the dangers of the diseases.

"You will not get a family where at least a member did not suffer Pneumonia in his lifetime," Prof Amin said, adding children with Pneumonia occupy over one-third of hospital beds across the country.

"But we can prevent it by ensuring exclusive breastfeeding from birth to six months & later homemade food & necessary vaccines."

According to Prof Amin, exclusive breastfeeding can curb Pneumonia by 15 to 23 percent by boosting their immune systems.

Early detection is imperative to combat the disease mostly caused by bacteria.

The common cold is typified with cough & runny nose. "But in case of Pneumonia, things will get worse," the child specialist said. "The child will start facing difficulty in breathing, apart from high fever."

He advised parents to take their kids to hospitals 'if breathing problem noticed'.

"But the disease should get priority as the government is aiming to achieve the targets of the Millennium Development Goals," Prof Amin said.

To meet the MDG target, the government is trying to reduce child mortality rate to 48 per 1,000 births by 2015.

According to health ministry, the figure stood at 60 per 1,000 births in 2009.

Microbiologist Dr Samir Kumar Saha sought support of Global Alliance for Vaccines & Immunisation (GAVI) to make vaccines for pneumococcus & haemophilus influenzae type B (Hib) available in Bangladesh.

Findings of the latest Bangladesh Demographic & Health Survey found 41 percent children under five underweight while the stunted rate was 43 percent & wasted 17 percent.

What is the path of your weight loss goal?

Working out & not losing any weight. Skimping on the right amount of aerobic activity might keep you from reaching your weight-loss goals.

You go to the gym, work out, but you still aren't losing any weight. What gives? It's a frustrating scenario but not an impossible one to change. Here are three reasons why you aren't losing weight at the gym & what to do about them.

You're Not Doing Enough [Intense] Cardio Aerobic activity is the most efficient way to burn calories, so make sure you are consistent with cardio workouts. We recommend doing at least 30-45 minutes of cardio, three to four times a week. It's also important to pick the right kind of cardio workout. Studies show that faster-paced workouts help release fat-burning hormones in the body & that interval training is key to losing unwanted belly fat. Still not convinced that you should step up your gym workouts? A recent study said that a 45-minute vigorous workout gets three times the net calories burned compared to the same 45 minutes spent walking; it also increases metabolic rate for up to 14 hours post-workout. To melt away unwanted pounds, choose high-intensity workouts like intervals, running, boot camp, or spin.
You Aren't Really Committed You showed up to the gym, which is awesome. But what's not awesome is how you might be spending your time there — weight loss is as much a mental game as a physical one. Mindlessly walking on the treadmill while flicking through a copy of Us Magazine isn't the best way to go about weight loss, & neither is talking yourself out of a workout once you're there. [You can lose a calorie burn of over 50 calories from just shaving five minutes off of a workout!] Commit yourself by finding a specific goal or personal reason that inspires you to lose the weight & use that as motivation to maintain your fitness routine. Along the way, set smaller goals for yourself & celebrate in some small way when you meet them. This will help you stay focused the entire way through.
You Don't Strength Train Even though cardio is key to weight loss, a good fitness program should incorporate one to two strength training sessions per week. Strength training can reduce overall body fat by three percent in just 10 weeks since muscle burns more calories than fat. & don't forget the after-burn: after an hour-long strength training session, the average woman burns an extra 100 calories over the next 24 hours. Maximize your time by rolling cardio & strength workouts into one. Circuit training intervals & bootcamp-style workouts focus on mixing bursts of cardio with serious strength training moves, but if you don't have time for a long session, perform supersets of compound moves instead.

Saturday, October 8, 2011

List of Seven Foods That Help You Lose Weight

Don't get sucked into the idea that food is your enemy when you're trying to lose weight. In fact, it's just the opposite: Befriend the right foods, & the pounds are much more likely to peel off than if you just try to cut calories across the board. Here, seven foods known to nutritionists to boost your body's fat-burning potential.
1. Oats

Wait a minute -- aren't oats a carb? Yes & no. Oats are a whole grain, & they're high on what nutritionists call the "satiety index," meaning oats have tremendous power to make you feel full. Not only that, they're also high in soluble fiber, so they cut cholesterol & blood fat. Oats digest slowly, so they don't raise your blood sugar, & they keep you feeling filled up well into the late morning. Old-fashioned steel-cut & rolled oats, with up to 5 grams of fiber per serving, are best, but even instant oatmeal has 3 to 4 grams of fiber per serving.
2. Eggs

Nutritionists have been trying for some years to restore the reputation of the lowly egg. No longer thought to be a cholesterol-booster (eggs contain a different type of cholesterol than that in humans), eggs are a concentrated form of animal protein without the added fat that comes with meat. Dietary studies have repeatedly found that when people eat an egg every morning in addition to (or instead of) toast or cereal, they lose twice as much weight as those who eat a breakfast that's dominated by carbs.
3. Skim milk

Studies in reputable publications such as the Journal of Obesity (in addition to the controversial ones funded by the National Dairy Council) show that the combination of calcium, vitamin D, & low-fat protein in skim milk & nonfat yogurt trigger weight loss & help build & maintain lean muscle.

4. Apples

To keep the pounds at bay, eat an apple -- or two -- a day. Numerous studies have found that eating an apple a half hour to an hour before a meal has the result of cutting the calories of the meal. Why? The fiber in the apple makes you feel full, so you eat less. Recent research suggests eating apples has other benefits, too; the antioxidants in apples appear to prevent metabolic syndrome, the combination of high cholesterol, high blood pressure, & prediabetes that tends to accompany thickening around the waist. Also, apples are high in pectin, which binds with water & limits the amount of fat your cells can absorb.
5. Red meat

Not exactly what you think of as a diet food, right? But research in the American Journal of Clinical Nutrition compared diet results for women who ate red meat & those who didn't, & the meat-eaters lost more weight. Experts think the dense protein in lean red meat helps you maintain muscle mass -- but of course this assumes you're exercising to build that muscle.
6. Cinnamon

This simple spice appears to have the power to help your body metabolize sugar, according to surprising data that came out of a USDA study involving diabetics. Eating as little as 1/4 to 2 teaspoons of cinnamon a day was found to reduce blood sugar levels & cut cholesterol from 10 to 25 percent. So add cinnamon to smoothies, sprinkle it on your cereal, or flavor your coffee with it -- particularly if you take your coffee with cream & sugar. The cinnamon will boost the health benefits of the coffee while helping your body rid itself of the added sugars.
7. Almonds & almond butter

Another counterintuitive choice; aren't nuts & nut butters supposed to be incredibly fattening? Well, almonds are calorie-dense, but they also pack a huge nutritional punch -- & they're particularly effective in counteracting cholesterol & triglycerides. One study in the American Journal of Clinical Nutrition found that eating almonds was as effective as taking a statin. Spreading almond butter on your morning toast gives you a nice protein boost while preventing the carbs in the toast from spiking your blood sugar.

Symptoms Women Are Likely to Ignore

Red, Sore, or Swollen Breast

Everyone knows to check for lumps in the breasts, but too often symptoms closer to the surface – which can indicate inflammatory breast cancer -- are overlooked. Some women describe noticing cellulite-like dimpled skin on an area of the breast. Others noticed that a breast felt swollen, hot, or irritated. Red or purplish discoloration is also cause for concern. Call your doctor about any unexplained changes in your breasts.

Nipple Changes

One of the most common changes women remember noticing before being diagnosed with breast cancer is a nipple that began to appear flattened, inverted, or turned sideways. "My nipple started looking like it was turned inside out," said one woman. In addition, inflammatory breast cancer also causes nipple problems, such as itchy, scaly, or crusty skin on the nipple -- so take any nipple changes seriously.

Bloating or Abdominal Weight Gain

The "my jeans don't fit" syndrome While this might sound too common a phenomenon to be considered a cancer symptom, consider this: Women diagnosed with ovarian cancer overwhelmingly report that unexplained abdominal bloating that came on fairly suddenly & continued on & off over a long period of time (as opposed to occurring a few days each month with PMS) was one of the main ways they knew something was wrong.

Feeling Full & Unable to Eat

This is another tip-off to ovarian cancer; survivors say they had no appetite & couldn't eat, even when they hadn't eaten for some time. Any woman who experiences noticeable bloating or weight gain numerous times (the diagnostic criteria is more than 13 times over the period of a month) -- especially if it's accompanied by pelvic pain or feeling overly full -- should call her doctor & ask for a pelvic ultrasound.

Unusually Heavy or Painful Periods or Bleeding Between Periods

Many women reported this as the tip-off to endometrial or uterine cancer. Unfortunately, many women also said their doctors weren't responsive, overlooking or misdiagnosing their complaints as normal perimenopause. Ask for a transvaginal ultrasound if you strongly suspect something more than routine heavy periods.

Most Likely We Ignore Cancer Symptoms

Symptoms of cancer you might overlook
Chest pain doesn't necessarily mean cancer, but it's an early sign for some patients.

Routine tests & checkups, like pap smears & colonoscopies, are important - but don't rely on tests alone to protect you from cancer. It's just as important to listen to your body & notice anything that's different, odd, or unexplainable. Although many of these symptoms could be caused by less serious conditions, they're worth getting checked out if they persist. You don't want to join the ranks of cancer patients who realize too late that symptoms they'd noticed for a long time could have sounded the alarm earlier, when cancer was easier to cure.

10 Things Your Skin Says About Your Health
For Both Men & Women

Wheezing or Shortness of Breath

One of the first signs lung cancer patients remember noticing when they look back is the inability to catch their breath. "I couldn't even walk across the yard without wheezing. I thought I had asthma, but how come I didn't have it before?" is how one woman described it. Thyroid cancer can also cause breathing problems if a nodule or tumor begins to press on the trachea, or windpipe. Any breathing difficulties that persist are reason to visit the doctor.

Swallowing Problems or Hoarseness

Most commonly associated with esophageal or throat cancer, difficulty swallowing is sometimes one of the first signs of lung cancer, too. A hoarse or low, husky voice or the feeling of something pressing on the throat can be an early indicator of thyroid cancer or a precancerous thyroid nodule, as can the feeling of having something stuck in your windpipe.

Frequent Fevers or Infections

These can be signs of leukemia, a cancer of the blood cells that starts in the bone marrow. Leukemia causes the marrow to produce abnormal white blood cells, which crowd out healthy white cells, sapping the body's infection-fighting capabilities. Often, doctors diagnose leukemia only after the patient has been in a number of times complaining of fever, achiness, & flu-like symptoms over an extended period of time.

Upset Stomach

As simple as it sounds, a good old-fashioned bellyache is what tipped off a number of lucky folks, whose doctors ordered ultrasounds & discovered early that they had tumors on their livers. Stomach cramps or frequent upset stomachs may indicate colorectal cancer; many cancer patients say their doctors thought they had ulcers.

Weakness & Fatigue

"I kept having to sit down at work, & one night I was too tired to drive home," said one woman in describing the fatigue that led her to discover she had leukemia. Generalized fatigue & weakness is a symptom of so many different kinds of cancer that you'll need to look at it in combination with other symptoms. But any time you feel exhausted without explanation & it doesn't respond to getting more sleep, talk to your doctor.

Unexplained Weight Loss

If you notice the pounds coming off & you haven't made changes to your diet or exercise regime, you need to ask why. Weight loss is an early sign of colon & other digestive cancers; it's also a sign of cancer that's spread to the liver, affecting your appetite & the ability of your body to rid itself of wastes.

Changes in Fingernails

Unexplained changes to the fingernails can be a sign of several types of cancer. A brown or black streak or dot under the nail can indicate skin cancer, while newly discovered "clubbing" -- enlargement of the ends of the fingers, with nails that curve down over the tips -- can be a sign of lung cancer. Pale or white nails can be an indication that your liver is not functioning properly, sometimes a sign of liver cancer.

Chronic "Acid Stomach" or Feeling Full After a Small Meal

The most common early sign of stomach cancer is pain in the upper or middle abdomen that feels like gas or heartburn. It may be aggravated by eating, so that you feel full when you haven't actually eaten much. What's particularly confusing is that the pain can be relieved by antacids, falsely confirming your conclusion that it was caused by acid in the stomach, when it's more than that. If you have frequent bouts of acid stomach, an unexplained abdominal ache, or a full feeling after meals even when you're eating less than normal, call your doctor.

Chronic Heartburn

If you just ate half a pizza, heartburn is expected. But if you have frequent episodes of heartburn or a constant low-level feeling of pain in the chest after eating, call your doctor & ask about screening for esophageal cancer. Gastroesophageal reflux disease (GERD) -- a condition in which stomach acid rises into the esophagus, causing heartburn & an acidic taste in the throat -- can trigger a condition called Barrett's esophagus, which can be a precursor of esophageal cancer.

Bowel Problems

Constipation, diarrhea, & changes in stools can all be signs of cancer. As with many other cancer symptoms, the way to tell if this is cause for concern is if it goes on for more than a few days without a clear cause, such as flu or food poisoning. People diagnosed with colon cancer say they noticed more frequent stools, as well as a feeling that their bowels weren't emptying completely. One of the early signs of pancreatic cancer is fatty stools, which can be recognized as frequent, large stools that are paler than normal & smelly. This is a sign that your body's not absorbing your food normally, & it should be brought to your doctor's attention.

Thursday, October 6, 2011

New innovation is coming up: The Particular Brain Fold That Helps People Distinguish between Imagination and Reality

Did you actually open the refrigerator a few minutes ago, or were you just thinking about it & imagined that you did? If you can remember correctly, you might have an extra fold in your brain.

A fold in the front brain called the paracingulate sulcus, or PCS, can apparently help people more accurately remember whether something was imagined or really happened, or which person actually said something. It's one of the final structural folds to develop before birth, & its size varies greatly in the general population, according to researchers at the University of Cambridge. People with the fold were significantly better at memory tasks than people without the fold, the researchers say.

The study, which was published in the Journal of Neuroscience, involved 53 healthy adult volunteers with no reported history of cognitive difficulties, according to a Cambridge news release. & everyone thought they had a good memory before the tests.

Participants were chosen based on MRI scans that showed a clear presence or absence of the PCS fold. Then they were presented with word pairs & half-pairs — like “Laurel & Hardy” or “Laurel & ?” In the second test, they were asked to imagine the other word, & then either they or the study leader actually said the word aloud.

Then they had a memory test, where they tried to remember whether they had actually seen the second word or just imagined it, & which person said the word out loud, Cambridge says. People with a PCS remembered correctly a lot more often.

This work has implications for some mental disorders like schizophrenia, in which the line between reality & imagination is unclear to the patient. In other studies, schizophrenic patients reportedly have had reduced PCS areas, according to Jon Simons of Cambridge’s Experimental Psychology department & Behavioural & Clinical Neuroscience Institute.

What to do about this isn’t clear — because the fold happens so shortly before birth, it’s not something that can be physically changed. But understanding the PCS’ role in memory & reality perception could have some impact on drug treatments for mental disorders.

Friday, September 30, 2011

Experimental Man

Growing Heart Cells Just for You

What can heart cells generated from my blood tell me about my risk for disease & about what drugs I should take if I get sick?

George Church on the Future of Stem Cells

Earlier this year, I had breakfast with George Church, professor of genetics & director of the Center for Computational Genetics at Harvard Medical School. (Click here to read my profile of Church in the New York Times.)

A pioneer in developing DNA sequencing technologies, & in researching everything from epigenetics & microbiomics to synthetic biology, Church has co-founded or advises over 20 companies. He also has launched the Personal Genome Project with a goal of sequencing the complete genomes of 100,000 volunteers.

When I asked Church what he was most excited about right now, he answered without hesitation: "I'm thinking a lot about using regeneration as the key to treatments & keeping people healthy."

TR: You mean regeneration using stem cells?

Church: Yes, induced pluripotent stem (IPS) cells (see, "Growing Heart Cells Just for You"). This is where I'm putting almost all of my chips these days, because it combines many of my interests--genomics, sequencing, epigenetics, synthetic biology, stem cells. I don't think people have fully appreciated how quickly adult stem cells & sequencing & synthetic biology have progressed. They have progressed by orders of magnitude since we got IPS. Before that, they basically weren't working.

Is this because IPS cells are relatively easy to create & to engineer?

You can use them to reprogram genomes--not sequence them, but to reprogram them genetically & epigenetically. In other words you make the minimum changes it takes to get them where you want them to be genetically & epigenetically & then you program the cells into tissues.

What do you mean?

Let's use stem cells in bone marrow as an example. They are easy to use & to get to work when you implant them in bone marrow. You might one day have three choices. You can have bone marrow from someone else that is matched to you, or that is from you, or bone marrow that is matched to you & comes to you, but is better than you. This better bone marrow might be [engineered to be] resistant to one virus, or to all viruses. It could have a bunch of alleles that you picked out of super centenarians, alleles that you have reason to believe are at least harmless & possibly helpful. So now you have choice, a patient who can take a good bone marrow that he might reject & you'll be on immunosuppressants your whole life. Or you might use your own, or your own that might fix the cancer, or your own enhanced bone marrow. & you will be able to do that for almost every stem cell population. Some of them are a little bit harder to replace, though.

Does IPS really work to accomplish this regeneration?

We have good evidence that you can create an entire mouse from IPS cells.

Has this been done?

This has been done. They have used IPS cells to grow a mouse, & they made IPS cells from that mouse. They're totipotent [able to make an entire organism], not merely pluripotent. We haven't done this for humans for obvious ethical reasons, but we will do it. As far as I know the mice have done fine.

But haven't there been some problems with mutations occurring with IPS-generated tissue?

We have a recent paper in Nature that shows that when you make human induced pluripotent stem cells you actually do get mutations in coding regions at a slightly elevated level. But I think this is temporary. We're going to use this information as an assay to make the process work better, to correct problems. You will be able to use this to improve the quality of gene therapy because that's been the problem with gene therapy the last ten years.

How far are we from testing that in humans?

Almost everything I've described has been done in rodents, so we're talking about years, not decades. It's shorter than the Human Genome Project [which took 13 years], not less expensive, but definitely shorter.

Could this technology be used to support personalized genomics, & can it verify a personal risk factor?

That's why we do IPS. We want to establish an IPS line for every single person who gets sequenced in the PGP [Personalized Genome Project, which aims to sequence 100,000 people].

When is regeneration likely to happen in humans?

There is much to be worked out. But here's the leap. If you want to accelerate this, you have to pick an intermediate target that doesn't sound so scary. So you'll start out with bone marrow patients. & you're going to basically make a synthetic version of that patient's bone marrow using IPS, which is going to work much better than the diseased bone marrow. & once this works that's going to catch on like wildfire. & then you'll do skin, & then you'll do every other stem cell you can get.

Who is going to do this?

The only way people are going to get this is through some brave soul. It will start with a sick person, & they will end up getting well, possibly more well than before they got sick. So you didn't just correct the sickness, you actually did more. & they'll give testimonials, & someone from the New York Times will interview them, & tell this appealing anecdote.

Will people who are, say, aging but not yet sick ever be able to use this technology?

I don't consider this medicine, it's preventive. I expect somebody who is truly brave, who has nothing wrong with them other than maybe the usual aging, saying: 'I want a bone marrow transplant', or intestinal, or whatever. & it will gain momentum from there.

Won't this cost a lot?

Initially it will be wealthy people who will try this. Ironically, wealthy people are often willing to be the guinea pigs that are really in a sense the front line of new technologies. They're the foot soldiers. They're willing to put themselves at risk, & to spend money on it.

Experimental Man

Growing Heart Cells Just for You

What can heart cells generated from my blood tell me about my risk for disease & about what drugs I should take if I get sick?

George Church on the Future of Stem Cells

Earlier this year, I had breakfast with George Church, professor of genetics & director of the Center for Computational Genetics at Harvard Medical School. (Click here to read my profile of Church in the New York Times.)

A pioneer in developing DNA sequencing technologies, & in researching everything from epigenetics & microbiomics to synthetic biology, Church has co-founded or advises over 20 companies. He also has launched the Personal Genome Project with a goal of sequencing the complete genomes of 100,000 volunteers.

When I asked Church what he was most excited about right now, he answered without hesitation: "I'm thinking a lot about using regeneration as the key to treatments & keeping people healthy."

TR: You mean regeneration using stem cells?

Church: Yes, induced pluripotent stem (IPS) cells (see, "Growing Heart Cells Just for You"). This is where I'm putting almost all of my chips these days, because it combines many of my interests--genomics, sequencing, epigenetics, synthetic biology, stem cells. I don't think people have fully appreciated how quickly adult stem cells & sequencing & synthetic biology have progressed. They have progressed by orders of magnitude since we got IPS. Before that, they basically weren't working.

Is this because IPS cells are relatively easy to create & to engineer?

You can use them to reprogram genomes--not sequence them, but to reprogram them genetically & epigenetically. In other words you make the minimum changes it takes to get them where you want them to be genetically & epigenetically & then you program the cells into tissues.

What do you mean?

Let's use stem cells in bone marrow as an example. They are easy to use & to get to work when you implant them in bone marrow. You might one day have three choices. You can have bone marrow from someone else that is matched to you, or that is from you, or bone marrow that is matched to you & comes to you, but is better than you. This better bone marrow might be [engineered to be] resistant to one virus, or to all viruses. It could have a bunch of alleles that you picked out of super centenarians, alleles that you have reason to believe are at least harmless & possibly helpful. So now you have choice, a patient who can take a good bone marrow that he might reject & you'll be on immunosuppressants your whole life. Or you might use your own, or your own that might fix the cancer, or your own enhanced bone marrow. & you will be able to do that for almost every stem cell population. Some of them are a little bit harder to replace, though.

Does IPS really work to accomplish this regeneration?

We have good evidence that you can create an entire mouse from IPS cells.

Has this been done?

This has been done. They have used IPS cells to grow a mouse, & they made IPS cells from that mouse. They're totipotent [able to make an entire organism], not merely pluripotent. We haven't done this for humans for obvious ethical reasons, but we will do it. As far as I know the mice have done fine.

But haven't there been some problems with mutations occurring with IPS-generated tissue?

We have a recent paper in Nature that shows that when you make human induced pluripotent stem cells you actually do get mutations in coding regions at a slightly elevated level. But I think this is temporary. We're going to use this information as an assay to make the process work better, to correct problems. You will be able to use this to improve the quality of gene therapy because that's been the problem with gene therapy the last ten years.

How far are we from testing that in humans?

Almost everything I've described has been done in rodents, so we're talking about years, not decades. It's shorter than the Human Genome Project [which took 13 years], not less expensive, but definitely shorter.

Could this technology be used to support personalized genomics, & can it verify a personal risk factor?

That's why we do IPS. We want to establish an IPS line for every single person who gets sequenced in the PGP [Personalized Genome Project, which aims to sequence 100,000 people].

When is regeneration likely to happen in humans?

There is much to be worked out. But here's the leap. If you want to accelerate this, you have to pick an intermediate target that doesn't sound so scary. So you'll start out with bone marrow patients. & you're going to basically make a synthetic version of that patient's bone marrow using IPS, which is going to work much better than the diseased bone marrow. & once this works that's going to catch on like wildfire. & then you'll do skin, & then you'll do every other stem cell you can get.

Who is going to do this?

The only way people are going to get this is through some brave soul. It will start with a sick person, & they will end up getting well, possibly more well than before they got sick. So you didn't just correct the sickness, you actually did more. & they'll give testimonials, & someone from the New York Times will interview them, & tell this appealing anecdote.

Will people who are, say, aging but not yet sick ever be able to use this technology?

I don't consider this medicine, it's preventive. I expect somebody who is truly brave, who has nothing wrong with them other than maybe the usual aging, saying: 'I want a bone marrow transplant', or intestinal, or whatever. & it will gain momentum from there.

Won't this cost a lot?

Initially it will be wealthy people who will try this. Ironically, wealthy people are often willing to be the guinea pigs that are really in a sense the front line of new technologies. They're the foot soldiers. They're willing to put themselves at risk, & to spend money on it.

Technologies for Healthier Living !!

New health-tracking apps, devices, & platforms from the Health 2.0 conference.

Band_Aid_like sensor that is affixed to the back, could soon stand in for the legions of mothers commanding us to sit up straight. This wearable sensor monitors posture & sends vibrations to your lower back if you slouch. It connects wirelessly to a smart phone app that helps guide correct posture & tracks posture over time. It also connects users to other resources for a healthy back. The app won a competition for best health app at the Body Computing conference at the University of Southern California last week.

Technologies for Healthier Living !!

New health-tracking apps, devices, & platforms from the Health 2.0 conference.

Band_Aid_like sensor that is affixed to the back, could soon stand in for the legions of mothers commanding us to sit up straight. This wearable sensor monitors posture & sends vibrations to your lower back if you slouch. It connects wirelessly to a smart phone app that helps guide correct posture & tracks posture over time. It also connects users to other resources for a healthy back. The app won a competition for best health app at the Body Computing conference at the University of Southern California last week.

Thursday, September 22, 2011

Philosophy and Psychology

Psychopathy is most commonly assessed with the PCL-R,82 which is a clinical rating scale with 20 items. Each of the items in the PCL-R is scored on a three-point (0, 1, 2) scale according to two factors.

PCL-R Factor 2 is associated with behavioral deficits or antisocial lifestyle,83 more specifically: reactive anger, anxiety, increased risk of suicide, criminality, & impulsive violence. PCL-R Factor 1, in contrast, is associated with personality deficits or aggressive narcissism,83 more specifically: extraversion & positive affect. Factor 1, the so-called core personality traits of psychopathy, may even be beneficial for the psychopath (in terms of non‑deviant social functioning).84 Both case history & a semi-structured interview are used in the analysis.

Because an individual's scores may have important consequences for his or her future, the potential for harm if the test is used or administered incorrectly is considerable. The test can only be considered valid if administered by a suitably qualified & experienced clinician under controlled conditions.3285
edit PCL-R items

The following findings are for research purposes only, & are not used in clinical diagnosis. These items cover the affective, interpersonal, & behavioral features. Each item is rated on a score from zero to two. The sum total determines the extent of a person's psychopathy.86

Factor 1
Aggressive narcissism

Glibness/superficial charm
Grandiose sense of self-worth
Pathological lying
Cunning/manipulative
Lack of remorse or guilt
Emotionally shallow
Callous/lack of empathy
Failure to accept responsibility for own actions

Factor 2
Socially deviant lifestyle

Need for stimulation/proneness to boredom
Parasitic lifestyle
Poor behavioral control
Promiscuous sexual behavior
Lack of realistic, long-term goals
Impulsiveness
Irresponsibility
Juvenile delinquency
Early behavioral problems
Revocation of conditional release
Many short-term marital relationships
Criminal versatility

One issue related to the assessment of individuals who may exhibit affective, interpersonal, & behavioral features associated with psychopathy is the ability to overcome gender myths when the psychopathy features are present in females.87 The Hare Psychopathy Checklist-Revised has both percentiles & T-score tables for male & female offenders.

In his 1941 book, Mask of Sanity, Hervey M. Cleckley introduced 16 behavioral characteristics of a psychopath: 90

Superficial charm & good "intelligence"*
Absence of delusions & other signs of irrational thinking*
Absence of nervousness or psychoneurotic manifestations*
Unreliability
Untruthfulness & insincerity
Lack of remorse & shame
Inadequately motivated antisocial behavior
Poor judgment & failure to learn by experience
Pathologic egocentricity & incapacity for love
General poverty in major affective reactions
Specific loss of insight
Unresponsiveness in general interpersonal relations
Fantastic & uninviting behavior with drink & sometimes without
Suicide threats rarely carried out*
Sex life impersonal, trivial, & poorly integrated
Failure to follow any life plan.

*These characteristics have since been depreciated.58

Hare Psychopathy Checklist
Main article: Hare Psychopathy Checklist

Psychopathy is most commonly assessed with the PCL-R,82 which is a clinical rating scale with 20 items. Each of the items in the PCL-R is scored on a three-point (0, 1, 2) scale according to two factors.

PCL-R Factor 2 is associated with behavioral deficits or antisocial lifestyle,83 more specifically: reactive anger, anxiety, increased risk of suicide, criminality, & impulsive violence. PCL-R Factor 1, in contrast, is associated with personality deficits or aggressive narcissism,83 more specifically: extraversion & positive affect. Factor 1, the so-called core personality traits of psychopathy, may even be beneficial for the psychopath (in terms of non‑deviant social functioning).84 Both case history & a semi-structured interview are used in the analysis.

Because an individual's scores may have important consequences for his or her future, the potential for harm if the test is used or administered incorrectly is considerable. The test can only be considered valid if administered by a suitably qualified & experienced clinician under controlled conditions.3285
edit PCL-R items

The following findings are for research purposes only, & are not used in clinical diagnosis. These items cover the affective, interpersonal, & behavioral features. Each item is rated on a score from zero to two. The sum total determines the extent of a person's psychopathy.86

Factor 1
Aggressive narcissism

Glibness/superficial charm
Grandiose sense of self-worth
Pathological lying
Cunning/manipulative
Lack of remorse or guilt
Emotionally shallow
Callous/lack of empathy
Failure to accept responsibility for own actions

Factor 2
Socially deviant lifestyle

Need for stimulation/proneness to boredom
Parasitic lifestyle
Poor behavioral control
Promiscuous sexual behavior
Lack of realistic, long-term goals
Impulsiveness
Irresponsibility
Juvenile delinquency
Early behavioral problems
Revocation of conditional release
Many short-term marital relationships
Criminal versatility

One issue related to the assessment of individuals who may exhibit affective, interpersonal, & behavioral features associated with psychopathy is the ability to overcome gender myths when the psychopathy features are present in females.87 The Hare Psychopathy Checklist-Revised has both percentiles & T-score tables for male & female offenders.
edit DSM & ICD

There are currently two widely established systems for classifying mental disorders — Chapter V of the International Classification of Diseases (ICD-10) produced by the World Health Organization (WHO) & the Diagnostic & Statistical Manual of Mental Disorders (DSM-IV) produced by the American Psychiatric Association (APA). Both list categories of disorders thought to be distinct types, & have deliberately converged their codes in recent revisions so that the manuals are often broadly comparable, although significant differences remain.

While previous versions of the DSM listed psychopathy as a personality disorder, currently it is not an diagnosis in these classifications. Labeling a person as a psychopath involves forensic measurement, using a diagnostic tool such as the Hare Psychopathy Checklist (PCL-R). The PCL-R is widely considered the "gold standard" for assessing psychopathy. Psychopathy is most strongly correlated with DSM-IV antisocial personality disorder (ASPD), & the ICD-10 antisocial personality disorder & dissocial personality disorder (DPD). However, the PCL-R criteria for identifying a psychopath are stricter than the diagnostic criteria for ASPD or DPD; psychopaths represent a subset of those with ASPD, & psychopaths' traits are more severe.86 A psychopath will score high on both PCL-R factors, whereas someone with ASPD who is not a psychopath will score high only on Factor 2.84

Some researchers are critical of the changed diagnostic criteria. Antisocial personality disorder is diagnosed via behavior & social deviant behaviors, whereas a diagnosis of psychopathy also includes affective & interpersonal personality factors. The Hare Psychopathy Checklist is better able to predict future criminality, violence, & recidivism than the diagnosis of ASPD using the DSM-III-R. Robert D. Hare writes that there are also differences between psychopaths & others on "processing & use of linguistic & emotional information" while such differences are small between those diagnosed with ASPD & not.8889 However, the Hare Psychopathy Checklist requires the use of a rather long interview & availability of considerable additional information89 as well as depending in part on judgements of character rather than observed behavior. Hare writes that the field trials for the DSM-IV found personality traits judgements to be as reliable as those diagnostic criteria relying only on behavior but that the personality traits criteria were dropped in part because it was feared that the average clinician would not use them correctly. Hare criticizes the instead used DSM-IV criteria for being poorly empirically tested. In addition, the introductory text description describes the personality characteristics typical of psychopathy, which Hare argues make the manual confusing & actually containing two different sets of criteria. He also argues that confusion regarding how to diagnose ASPD, confusion regarding the difference between ASPD & psychopathy, as well as the differing future prognoses regarding recidivism & treatability, may have serious consequences in settings such as court cases where psychopathy is often seen as aggravating the crime.88

The DSM-V working party is recommending a revision of antisocial personality disorder to include "Antisocial/Psychopathic Type", with the diagnostic criteria having a greater emphasis on character than on behavior.5
edit Cleckley Checklist

In his 1941 book, Mask of Sanity, Hervey M. Cleckley introduced 16 behavioral characteristics of a psychopath: 90

Superficial charm & good "intelligence"*
Absence of delusions & other signs of irrational thinking*
Absence of nervousness or psychoneurotic manifestations*
Unreliability
Untruthfulness & insincerity
Lack of remorse & shame
Inadequately motivated antisocial behavior
Poor judgment & failure to learn by experience
Pathologic egocentricity & incapacity for love
General poverty in major affective reactions
Specific loss of insight
Unresponsiveness in general interpersonal relations
Fantastic & uninviting behavior with drink & sometimes without
Suicide threats rarely carried out*
Sex life impersonal, trivial, & poorly integrated
Failure to follow any life plan.

*These characteristics have since been depreciated.58
edit Other diagnostic considerations
edit Primary-secondary distinction

Primary psychopathy was defined by those following this theory as the root disorder in patients diagnosed with it, whereas secondary psychopathy was defined as an aspect of another psychiatric disorder or social circumstances.91 Today, primary psychopaths are considered to have mostly Factor 1 traits from the PCL-R (arrogance, callousness, manipulativeness, lying) whereas secondary psychopaths have a majority of Factor 2 traits (impulsivity, boredom proneness, irresponsibility, lack of long-term goals).92

The primary psychopath engages in antisocial behavior as a result of a genetic-biological predisposition directed by particular psychodynamic forces that occur in infancy. The secondary psychopath's antisocial behavior is the result of strictly environmental forces (e.g., membership in a deviant group) that occur at developmental stages beyond infancy. The fundamental distinction between the two is the ability to attach emotionally to others & to experience the natural anxiety associated with human attachment. The primary psychopath forms no attachments as a result of early developmental obstruction, & thus is capable of harming others with little or no anxiety. The secondary psychopath forms human attachments, possibly to deviant subgroups, or not. However, whether or not the secondary psychopath appears to be attached to others, emotional connection to other human beings is present.3

Secondary psychopaths show normal to above-normal physiological responses to (perceived) potential threats; their crimes tend to be unplanned & impulsive with little thought of the consequences.17 According to those using this theory, this type have hot tempers & are prone to reactive aggression. They experience normal to above-normal levels of anxiety but are nevertheless highly stimulus-seeking & have trouble tolerating boredom. Their lifestyle may lead to depression & even suicide.

Mealey uses the term "primary psychopathy" to differentiate between psychopathy that is biological in origin & "secondary psychopathy" that results from a combination of genetic & environmental influences.93 Lykken prefers sociopathy to describe the latter.

Sellbom & Ben-Porath (2005) describe the distinction:

Some people who engage in violent behavior possess psychopathic personality traits, such as callousness, grandiosity, & fearlessness, & presumably engage in such conduct because they care little about others. Others are impulsive & experience considerable anger, anxiety, & distress & may commit violent acts as a reaction to negative emotions, which are sometimes referred to as "crimes of passion." Indeed, the distinction between primary & secondary psychopathy (including so-called neurotic psychopathy) has long been noted in the psychopathy literature (Karpman, 1947; Lykken, 1995).94

This distinction closely resembles the distinction between instrumental & impulsive/reactive crime/violence in the field of criminology.citation needed

Joseph P. Newman et al., who use this concept of psychopathy, have validated David T. Lykken's conceptualization of psychopathy subtypes in relation to Gray's behavioral activation system & behavioral inhibition system.95 Newman et al. found measures of primary psychopathy to be negatively correlated with Gray's behavioral inhibition system, a construct intended to measure behavioral inhibition from cues of punishment or nonreward.95 In contrast, measures of secondary psychopathy to be positively correlated with Gray's behavioral activation system, a construct intended to measure sensitivity to cues of behavioral approach.95
edit Psychopathy vs. sociopathy

Hare writes that the difference between sociopathy & psychopathy may "reflect the user's views on the origins & determinates of the disorder." The term sociopathy may be preferred by sociologists that see the causes as due to social factors. The term psychopathy may be preferred by psychologists who see the causes as due to a combination of psychological, genetic, & environmental factors.96

David T. Lykken proposes psychopathy & sociopathy are two distinct kinds of antisocial personality disorder. He believes psychopaths are born with temperamental differences such as impulsivity, cortical underarousal, & fearlessness that lead them to risk-seeking behavior & an inability to internalize social norms. On the other hand, he claims sociopaths have relatively normal temperaments; their personality disorder being more an effect of negative sociological factors like parental neglect, delinquent peers, poverty, & extremely low or extremely high intelligence. Both personality disorders are the result of an interaction between genetic predispositions & environmental factors, but psychopathy leans towards the hereditary whereas sociopathy tends towards the environmental.92
edit Three-factor model

Recent statistical analysis using confirmatory factor analysis by Cooke & Michie97 indicated a three-factor structure, with those items from factor 2 strictly relating to antisocial behaviour (criminal versatility, juvenile delinquency, revocation of conditional release, early behavioural problems, & poor behavioural controls) removed from the final model. The remaining items are divided into three factors: Arrogant & Deceitful Interpersonal Style, Deficient Affective Experience, & Impulsive & Irresponsible Behavioural Style.97

Hare & colleagues have published detailed critiques of the Cooke & Michie hierarchical ‘three’-factor model, citing severe statistical problems. Hare & colleagues note that the Cooke & Michie model actually contains ten factors, & results in impossible parameters (negative variances). Hare & colleagues also note conceptual problems with this model.98
edit Discrete vs. continuous

As part of the larger debate on whether personality disorders are distinct from normal personality, or if they are extremes on various dimensions of normal personality, is the debate on whether psychopathy represents something "qualitatively different" from normal personality, or a "continuous dimension" shading from normality into severely psychopathic. Otto Kernberg believed psychopathy should fall under a spectrum of pathological narcissism, that ranged from narcissistic personality on the low end, malignant narcissism in the middle, & psychopathy at the high end.99

Early taxonometric analysis from Harris & colleagues100 indicated a discrete category may underlie psychopathy, but this was only found for the behavioural Factor 2 items, indicating this analysis may be related to Antisocial Personality Disorder rather than psychopathy per se. Marcus, John, & Edens more recently performed a series of statistical analysis on previously attained PCL–R & PPI scores & concluded psychopathy may best be conceptualized as having a "dimensional latent structure" like depression.101
edit Comorbidity

Psychopaths may have various others mental conditions,102 although, in contrast to people with antisocial personality disorder, comorbidity among psychopaths is generally found to be low.103104

Substance abuse has been associated with psychopathy,105 particularly Factor 2 (anti-social behaviour), but not Factor 1 (emotional) scores of the PCL-R.102103 Conduct disorder & ADHD have both been associated with psychopathy; which may be explained by disruption to dorsolateral prefrontal cortex. This area is associated with executive function, which is affected in all three disorders.102

There is some evidence of an association between ASPD & other personality disorders (i.e. histrionic, narcissistic & borderline personality disorders),103 however, evidence for a link with psychopathy is more tentative.104

Anxiety may be associated positively with antisocial behaviour, but it is inversely associated with Factor I (emotional) scores on the PCL-R.102 Depression is inversely associated with psychopathy.102 There is no conclusive evidence for a link between psychopathy & schizophrenia.102104

It has been suggested that psychopathy may be comorbid with several other diagnoses than these,105 however limited work on comorbidity has been carried out. This may be because of difficulties in using inpatient groups from certain institutions to assess comorbidity, owing to the likelihood of some bias in sample selection.102 Furthermore, comorbidity may be more reflective of poor discriminant validity of categories in the DSM-IV than reflective of underlying aetiologically separate conditions.103
edit Psychopathy & Sexual Deviance

Sexual preferences are usually considered deviant when they stray statistically from the norm and, when acted on, tend to inflict unwanted harm on oneself or others (Lalumière & Quinsey, 1999). In a study conducted by Barbaree et al. (1994) using Penile Plethysmography, psychopaths showed more increased penile blood flow than did controls upon being shown deviant visual & auditory stimuli. This may be due to the psychopath’s complete disregard for social norms & lack of attachment to others. The desire to be socially accepted is so deeply ingrained into the minds & personalities of average humans, that to some extent this dictates our sexual feelings. While the psychopath will attempt to blend in, their undisclosed desires are completely uninhibited by social standards. There is also evidence to suggest that psychopathic sexual offenders use more violence against their victims than do nonpsychopathic sexual offenders, suggesting that the psychopath may have a higher propensity to be sexually sadistic. Woodworth et al. (2003) examined the correlation between PCL-R scores & types of aggression expressed in a sample of 38 sexual murderers. 84.7% of these individuals scored in the moderate to high range (scores significantly higher than those of a group of nonsexual murderers). Also, murders committed by psychopaths (those with a score of 20 or above) showed more gratuitous & sadistic violence than those of nonpsychopaths. 82.4% of psychopaths committed sadistic violence against their victims, compared to only 52.6% of nonpsychopaths.
edit Epidemiology

It is estimated that approximately one percent of the general population are psychopaths.12 A 2009 British study reported a community prevalence of 0.6%, consistent with the estimate given by the screening version of the psychopathy checklist.106

The psychologist Robert Hare in his book, "Without Conscience: The Disturbing World of Psychopaths among Us", argues that psychopathy has a genetic predisposition. He goes on to state that many psychopaths have a pattern of mating with, & quickly abandoning women, & as a result, have a high fertility rate. These children may inherit a predisposition to psychopathy. Hare describes the implications as chilling.107
edit Among criminals

A 2002 literature review of studies on mental disorders in prisoners stated that 47% of male prisoners & 21% of female prisoners had anti-social personality disorder.108 According to an unsourced article in popular science magazine Scientific American, studies indicate that about 25% of prison inmates meet diagnostic criteria for psychopathy.9 A 2009 study of British prisoners found a prevalence for "categorically diagnosed psychopathy" of 7.7% in men & 1.9% in women.109

Homocides by psychopaths were almost always (93.3%) done in "cold blood" & premeditated in a 2002 study. For non-psychopaths the figure was 48.4% due to a much larger share of "crimes of passion".110

Despite having several characteristics that may seem useful to terrorists, there is little evidence that the majority of terrorists are psychopaths. Other characteristics such self-centeredness, unreliability, poor behavioral controls, & unusual behaviors may be disadvantages or make psychopaths unwilling to sacrifice themselves for a perceived higher cause.111 Indeed, the increased narcissism may produce the attitude that there is no higher cause than the pleasure of the psychopath.

A 2011 study of conditional releases for Canadian male federal offenders found that psychopathy was related to more violent & non-violent offences but not more sexual offences. For child molesters psychopathy was associated with more offences. Despite "their extensive criminal histories & high recidivism rate", psychopaths showed "a great proficiency in persuading parole boards to release them into the community." "High-psychopathy offenders (both sexual & non-sexual offenders) were about 2.5 times more likely to be granted conditional release than non-psychopathic offenders."112
edit Management
edit Clinical management

In practice, mental health professionals rarely treat psychopathic personality disorders as they are often considered untreatable & no interventions have proved to be effective. However, some of the difficulty has been attributed to the lack of clarity about the concept & diagnosis of psychopathy; the threat of danger to staff, or deceit or poor motivation from patients; & a lack of follow-up to test effectiveness. Despite pessimism, as of 1999, treatment of patients still takes place in a variety of psychiatric hospitals & secure units, & the research has indicated that some individuals do show some improvements when the right treatment is identified, & that longer periods of therapy often produce better results.113

It has been shown that punishment & behavior modification techniques do not improve the behavior of psychopaths. Psychopathic individuals have been regularly observed to become more cunning & better able to hide their behaviour. It has been suggested that traditional therapeutic approaches actually make psychopaths more adept at manipulating others & concealing their behavior. They are generally considered to be not only incurable but also untreatable.8

However, some researchers suggest that psychopaths can benefit as much as others from psychological treatment, at least in terms of criminal behaviors even if not on the central personality traits.9 For example, one therapeutic approach to juveniles reports reduced re-offending over a two year period compared to usual care.114
edit Legal response
edit United Kingdom

In the United Kingdom, "Psychopathic Disorder" was legally defined in the Mental Health Act (UK)115 as, "a persistent disorder or disability of mind (whether or not including significant impairment of intelligence) which results in abnormally aggressive or seriously irresponsible conduct on the part of the person concerned." This term, which did not equate to psychopathy, was intended to reflect the presence of a personality disorder, in terms of conditions for detention under the Mental Health Act 1983. With the subsequent amendments to the Mental Health Act 1983 within the Mental Health Act 2007, the term 'psychopathic disorder' has been abolished, with all conditions for detention (e.g. mental illness, personality disorder, etc.) now being contained within the generic term of 'mental disorder'.

In England & Wales, the diagnosis of dissocial personality disorder is grounds for detention in secure psychiatric hospitals under the Mental Health Act if they have committed serious crimes, but since such individuals are disruptive for other patients & not responsive to treatment this alternative to prison is not often used.116
edit United States

Psychopathy has quite separate legal & judicial definitions that should not be confused with the medical definition. The American Psychiatric Association is vigorously opposing any non-medical or legal definition of what purports to be a medical condition "without regard for scientific & clinical knowledge." 117 Various states & nations have at various times enacted laws specific to dealing with psychopaths.

In the United States, approximately 20 states currently have provisions for the involuntary civil commitment for sex offenders or sexual predators, under Sexually violent predator acts, avoiding the use of the term "psychopath." These statutes & provisions are controversial & are being reviewed by the U.S. Supreme Court as a violation of a person's Fourteenth Amendment rights.118 (See Foucha v. Louisiana for an example.119)

Washington

Washington State Legislature 120 defines a "Psychopathic personality" to mean "the existence in any person of such hereditary, congenital or acquired condition affecting the emotional or volitional rather than the intellectual field & manifested by anomalies of such character as to render satisfactory social adjustment of such person difficult or impossible."118 The same statute defines the "sexual psychopath" as "any person who is affected in a form of psychoneurosis or in a form of psychopathic personality, which form predisposes such person to the commission of sexual offenses in a degree constituting him a menace to the health or safety of others" for prison sentencing purposes in the Sentencing Reform Act of 1981.120

California

California enacted a psychopathic offender law in 1939, since greatly outmoded & revised,121 that defined a psychopath solely in terms of offenders with a predisposition "to the commission of sexual offenses against children." A 1941 law122 attempted to further clarify this to the point where anyone examined & found to be psychopathic was to be committed to a state hospital & anyone else was to be sentenced by the courts. However, these laws were enacted years before the American Psychiatric Association began publishing the Diagnostic & Statistical Manual of Mental Disorders which is used today for diagnosis & does not include "psychopathic offender". Hence, these laws are of historical interest only.

Philosophy and Psychology

Psychopathy is most commonly assessed with the PCL-R,82 which is a clinical rating scale with 20 items. Each of the items in the PCL-R is scored on a three-point (0, 1, 2) scale according to two factors.

PCL-R Factor 2 is associated with behavioral deficits or antisocial lifestyle,83 more specifically: reactive anger, anxiety, increased risk of suicide, criminality, & impulsive violence. PCL-R Factor 1, in contrast, is associated with personality deficits or aggressive narcissism,83 more specifically: extraversion & positive affect. Factor 1, the so-called core personality traits of psychopathy, may even be beneficial for the psychopath (in terms of non‑deviant social functioning).84 Both case history & a semi-structured interview are used in the analysis.

Because an individual's scores may have important consequences for his or her future, the potential for harm if the test is used or administered incorrectly is considerable. The test can only be considered valid if administered by a suitably qualified & experienced clinician under controlled conditions.3285
edit PCL-R items

The following findings are for research purposes only, & are not used in clinical diagnosis. These items cover the affective, interpersonal, & behavioral features. Each item is rated on a score from zero to two. The sum total determines the extent of a person's psychopathy.86

Factor 1
Aggressive narcissism

Glibness/superficial charm
Grandiose sense of self-worth
Pathological lying
Cunning/manipulative
Lack of remorse or guilt
Emotionally shallow
Callous/lack of empathy
Failure to accept responsibility for own actions

Factor 2
Socially deviant lifestyle

Need for stimulation/proneness to boredom
Parasitic lifestyle
Poor behavioral control
Promiscuous sexual behavior
Lack of realistic, long-term goals
Impulsiveness
Irresponsibility
Juvenile delinquency
Early behavioral problems
Revocation of conditional release
Many short-term marital relationships
Criminal versatility

One issue related to the assessment of individuals who may exhibit affective, interpersonal, & behavioral features associated with psychopathy is the ability to overcome gender myths when the psychopathy features are present in females.87 The Hare Psychopathy Checklist-Revised has both percentiles & T-score tables for male & female offenders.

In his 1941 book, Mask of Sanity, Hervey M. Cleckley introduced 16 behavioral characteristics of a psychopath: 90

Superficial charm & good "intelligence"*
Absence of delusions & other signs of irrational thinking*
Absence of nervousness or psychoneurotic manifestations*
Unreliability
Untruthfulness & insincerity
Lack of remorse & shame
Inadequately motivated antisocial behavior
Poor judgment & failure to learn by experience
Pathologic egocentricity & incapacity for love
General poverty in major affective reactions
Specific loss of insight
Unresponsiveness in general interpersonal relations
Fantastic & uninviting behavior with drink & sometimes without
Suicide threats rarely carried out*
Sex life impersonal, trivial, & poorly integrated
Failure to follow any life plan.

*These characteristics have since been depreciated.58

Hare Psychopathy Checklist
Main article: Hare Psychopathy Checklist

Psychopathy is most commonly assessed with the PCL-R,82 which is a clinical rating scale with 20 items. Each of the items in the PCL-R is scored on a three-point (0, 1, 2) scale according to two factors.

PCL-R Factor 2 is associated with behavioral deficits or antisocial lifestyle,83 more specifically: reactive anger, anxiety, increased risk of suicide, criminality, & impulsive violence. PCL-R Factor 1, in contrast, is associated with personality deficits or aggressive narcissism,83 more specifically: extraversion & positive affect. Factor 1, the so-called core personality traits of psychopathy, may even be beneficial for the psychopath (in terms of non‑deviant social functioning).84 Both case history & a semi-structured interview are used in the analysis.

Because an individual's scores may have important consequences for his or her future, the potential for harm if the test is used or administered incorrectly is considerable. The test can only be considered valid if administered by a suitably qualified & experienced clinician under controlled conditions.3285
edit PCL-R items

The following findings are for research purposes only, & are not used in clinical diagnosis. These items cover the affective, interpersonal, & behavioral features. Each item is rated on a score from zero to two. The sum total determines the extent of a person's psychopathy.86

Factor 1
Aggressive narcissism

Glibness/superficial charm
Grandiose sense of self-worth
Pathological lying
Cunning/manipulative
Lack of remorse or guilt
Emotionally shallow
Callous/lack of empathy
Failure to accept responsibility for own actions

Factor 2
Socially deviant lifestyle

Need for stimulation/proneness to boredom
Parasitic lifestyle
Poor behavioral control
Promiscuous sexual behavior
Lack of realistic, long-term goals
Impulsiveness
Irresponsibility
Juvenile delinquency
Early behavioral problems
Revocation of conditional release
Many short-term marital relationships
Criminal versatility

One issue related to the assessment of individuals who may exhibit affective, interpersonal, & behavioral features associated with psychopathy is the ability to overcome gender myths when the psychopathy features are present in females.87 The Hare Psychopathy Checklist-Revised has both percentiles & T-score tables for male & female offenders.
edit DSM & ICD

There are currently two widely established systems for classifying mental disorders — Chapter V of the International Classification of Diseases (ICD-10) produced by the World Health Organization (WHO) & the Diagnostic & Statistical Manual of Mental Disorders (DSM-IV) produced by the American Psychiatric Association (APA). Both list categories of disorders thought to be distinct types, & have deliberately converged their codes in recent revisions so that the manuals are often broadly comparable, although significant differences remain.

While previous versions of the DSM listed psychopathy as a personality disorder, currently it is not an diagnosis in these classifications. Labeling a person as a psychopath involves forensic measurement, using a diagnostic tool such as the Hare Psychopathy Checklist (PCL-R). The PCL-R is widely considered the "gold standard" for assessing psychopathy. Psychopathy is most strongly correlated with DSM-IV antisocial personality disorder (ASPD), & the ICD-10 antisocial personality disorder & dissocial personality disorder (DPD). However, the PCL-R criteria for identifying a psychopath are stricter than the diagnostic criteria for ASPD or DPD; psychopaths represent a subset of those with ASPD, & psychopaths' traits are more severe.86 A psychopath will score high on both PCL-R factors, whereas someone with ASPD who is not a psychopath will score high only on Factor 2.84

Some researchers are critical of the changed diagnostic criteria. Antisocial personality disorder is diagnosed via behavior & social deviant behaviors, whereas a diagnosis of psychopathy also includes affective & interpersonal personality factors. The Hare Psychopathy Checklist is better able to predict future criminality, violence, & recidivism than the diagnosis of ASPD using the DSM-III-R. Robert D. Hare writes that there are also differences between psychopaths & others on "processing & use of linguistic & emotional information" while such differences are small between those diagnosed with ASPD & not.8889 However, the Hare Psychopathy Checklist requires the use of a rather long interview & availability of considerable additional information89 as well as depending in part on judgements of character rather than observed behavior. Hare writes that the field trials for the DSM-IV found personality traits judgements to be as reliable as those diagnostic criteria relying only on behavior but that the personality traits criteria were dropped in part because it was feared that the average clinician would not use them correctly. Hare criticizes the instead used DSM-IV criteria for being poorly empirically tested. In addition, the introductory text description describes the personality characteristics typical of psychopathy, which Hare argues make the manual confusing & actually containing two different sets of criteria. He also argues that confusion regarding how to diagnose ASPD, confusion regarding the difference between ASPD & psychopathy, as well as the differing future prognoses regarding recidivism & treatability, may have serious consequences in settings such as court cases where psychopathy is often seen as aggravating the crime.88

The DSM-V working party is recommending a revision of antisocial personality disorder to include "Antisocial/Psychopathic Type", with the diagnostic criteria having a greater emphasis on character than on behavior.5
edit Cleckley Checklist

In his 1941 book, Mask of Sanity, Hervey M. Cleckley introduced 16 behavioral characteristics of a psychopath: 90

Superficial charm & good "intelligence"*
Absence of delusions & other signs of irrational thinking*
Absence of nervousness or psychoneurotic manifestations*
Unreliability
Untruthfulness & insincerity
Lack of remorse & shame
Inadequately motivated antisocial behavior
Poor judgment & failure to learn by experience
Pathologic egocentricity & incapacity for love
General poverty in major affective reactions
Specific loss of insight
Unresponsiveness in general interpersonal relations
Fantastic & uninviting behavior with drink & sometimes without
Suicide threats rarely carried out*
Sex life impersonal, trivial, & poorly integrated
Failure to follow any life plan.

*These characteristics have since been depreciated.58
edit Other diagnostic considerations
edit Primary-secondary distinction

Primary psychopathy was defined by those following this theory as the root disorder in patients diagnosed with it, whereas secondary psychopathy was defined as an aspect of another psychiatric disorder or social circumstances.91 Today, primary psychopaths are considered to have mostly Factor 1 traits from the PCL-R (arrogance, callousness, manipulativeness, lying) whereas secondary psychopaths have a majority of Factor 2 traits (impulsivity, boredom proneness, irresponsibility, lack of long-term goals).92

The primary psychopath engages in antisocial behavior as a result of a genetic-biological predisposition directed by particular psychodynamic forces that occur in infancy. The secondary psychopath's antisocial behavior is the result of strictly environmental forces (e.g., membership in a deviant group) that occur at developmental stages beyond infancy. The fundamental distinction between the two is the ability to attach emotionally to others & to experience the natural anxiety associated with human attachment. The primary psychopath forms no attachments as a result of early developmental obstruction, & thus is capable of harming others with little or no anxiety. The secondary psychopath forms human attachments, possibly to deviant subgroups, or not. However, whether or not the secondary psychopath appears to be attached to others, emotional connection to other human beings is present.3

Secondary psychopaths show normal to above-normal physiological responses to (perceived) potential threats; their crimes tend to be unplanned & impulsive with little thought of the consequences.17 According to those using this theory, this type have hot tempers & are prone to reactive aggression. They experience normal to above-normal levels of anxiety but are nevertheless highly stimulus-seeking & have trouble tolerating boredom. Their lifestyle may lead to depression & even suicide.

Mealey uses the term "primary psychopathy" to differentiate between psychopathy that is biological in origin & "secondary psychopathy" that results from a combination of genetic & environmental influences.93 Lykken prefers sociopathy to describe the latter.

Sellbom & Ben-Porath (2005) describe the distinction:

Some people who engage in violent behavior possess psychopathic personality traits, such as callousness, grandiosity, & fearlessness, & presumably engage in such conduct because they care little about others. Others are impulsive & experience considerable anger, anxiety, & distress & may commit violent acts as a reaction to negative emotions, which are sometimes referred to as "crimes of passion." Indeed, the distinction between primary & secondary psychopathy (including so-called neurotic psychopathy) has long been noted in the psychopathy literature (Karpman, 1947; Lykken, 1995).94

This distinction closely resembles the distinction between instrumental & impulsive/reactive crime/violence in the field of criminology.citation needed

Joseph P. Newman et al., who use this concept of psychopathy, have validated David T. Lykken's conceptualization of psychopathy subtypes in relation to Gray's behavioral activation system & behavioral inhibition system.95 Newman et al. found measures of primary psychopathy to be negatively correlated with Gray's behavioral inhibition system, a construct intended to measure behavioral inhibition from cues of punishment or nonreward.95 In contrast, measures of secondary psychopathy to be positively correlated with Gray's behavioral activation system, a construct intended to measure sensitivity to cues of behavioral approach.95
edit Psychopathy vs. sociopathy

Hare writes that the difference between sociopathy & psychopathy may "reflect the user's views on the origins & determinates of the disorder." The term sociopathy may be preferred by sociologists that see the causes as due to social factors. The term psychopathy may be preferred by psychologists who see the causes as due to a combination of psychological, genetic, & environmental factors.96

David T. Lykken proposes psychopathy & sociopathy are two distinct kinds of antisocial personality disorder. He believes psychopaths are born with temperamental differences such as impulsivity, cortical underarousal, & fearlessness that lead them to risk-seeking behavior & an inability to internalize social norms. On the other hand, he claims sociopaths have relatively normal temperaments; their personality disorder being more an effect of negative sociological factors like parental neglect, delinquent peers, poverty, & extremely low or extremely high intelligence. Both personality disorders are the result of an interaction between genetic predispositions & environmental factors, but psychopathy leans towards the hereditary whereas sociopathy tends towards the environmental.92
edit Three-factor model

Recent statistical analysis using confirmatory factor analysis by Cooke & Michie97 indicated a three-factor structure, with those items from factor 2 strictly relating to antisocial behaviour (criminal versatility, juvenile delinquency, revocation of conditional release, early behavioural problems, & poor behavioural controls) removed from the final model. The remaining items are divided into three factors: Arrogant & Deceitful Interpersonal Style, Deficient Affective Experience, & Impulsive & Irresponsible Behavioural Style.97

Hare & colleagues have published detailed critiques of the Cooke & Michie hierarchical ‘three’-factor model, citing severe statistical problems. Hare & colleagues note that the Cooke & Michie model actually contains ten factors, & results in impossible parameters (negative variances). Hare & colleagues also note conceptual problems with this model.98
edit Discrete vs. continuous

As part of the larger debate on whether personality disorders are distinct from normal personality, or if they are extremes on various dimensions of normal personality, is the debate on whether psychopathy represents something "qualitatively different" from normal personality, or a "continuous dimension" shading from normality into severely psychopathic. Otto Kernberg believed psychopathy should fall under a spectrum of pathological narcissism, that ranged from narcissistic personality on the low end, malignant narcissism in the middle, & psychopathy at the high end.99

Early taxonometric analysis from Harris & colleagues100 indicated a discrete category may underlie psychopathy, but this was only found for the behavioural Factor 2 items, indicating this analysis may be related to Antisocial Personality Disorder rather than psychopathy per se. Marcus, John, & Edens more recently performed a series of statistical analysis on previously attained PCL–R & PPI scores & concluded psychopathy may best be conceptualized as having a "dimensional latent structure" like depression.101
edit Comorbidity

Psychopaths may have various others mental conditions,102 although, in contrast to people with antisocial personality disorder, comorbidity among psychopaths is generally found to be low.103104

Substance abuse has been associated with psychopathy,105 particularly Factor 2 (anti-social behaviour), but not Factor 1 (emotional) scores of the PCL-R.102103 Conduct disorder & ADHD have both been associated with psychopathy; which may be explained by disruption to dorsolateral prefrontal cortex. This area is associated with executive function, which is affected in all three disorders.102

There is some evidence of an association between ASPD & other personality disorders (i.e. histrionic, narcissistic & borderline personality disorders),103 however, evidence for a link with psychopathy is more tentative.104

Anxiety may be associated positively with antisocial behaviour, but it is inversely associated with Factor I (emotional) scores on the PCL-R.102 Depression is inversely associated with psychopathy.102 There is no conclusive evidence for a link between psychopathy & schizophrenia.102104

It has been suggested that psychopathy may be comorbid with several other diagnoses than these,105 however limited work on comorbidity has been carried out. This may be because of difficulties in using inpatient groups from certain institutions to assess comorbidity, owing to the likelihood of some bias in sample selection.102 Furthermore, comorbidity may be more reflective of poor discriminant validity of categories in the DSM-IV than reflective of underlying aetiologically separate conditions.103
edit Psychopathy & Sexual Deviance

Sexual preferences are usually considered deviant when they stray statistically from the norm and, when acted on, tend to inflict unwanted harm on oneself or others (Lalumière & Quinsey, 1999). In a study conducted by Barbaree et al. (1994) using Penile Plethysmography, psychopaths showed more increased penile blood flow than did controls upon being shown deviant visual & auditory stimuli. This may be due to the psychopath’s complete disregard for social norms & lack of attachment to others. The desire to be socially accepted is so deeply ingrained into the minds & personalities of average humans, that to some extent this dictates our sexual feelings. While the psychopath will attempt to blend in, their undisclosed desires are completely uninhibited by social standards. There is also evidence to suggest that psychopathic sexual offenders use more violence against their victims than do nonpsychopathic sexual offenders, suggesting that the psychopath may have a higher propensity to be sexually sadistic. Woodworth et al. (2003) examined the correlation between PCL-R scores & types of aggression expressed in a sample of 38 sexual murderers. 84.7% of these individuals scored in the moderate to high range (scores significantly higher than those of a group of nonsexual murderers). Also, murders committed by psychopaths (those with a score of 20 or above) showed more gratuitous & sadistic violence than those of nonpsychopaths. 82.4% of psychopaths committed sadistic violence against their victims, compared to only 52.6% of nonpsychopaths.
edit Epidemiology

It is estimated that approximately one percent of the general population are psychopaths.12 A 2009 British study reported a community prevalence of 0.6%, consistent with the estimate given by the screening version of the psychopathy checklist.106

The psychologist Robert Hare in his book, "Without Conscience: The Disturbing World of Psychopaths among Us", argues that psychopathy has a genetic predisposition. He goes on to state that many psychopaths have a pattern of mating with, & quickly abandoning women, & as a result, have a high fertility rate. These children may inherit a predisposition to psychopathy. Hare describes the implications as chilling.107
edit Among criminals

A 2002 literature review of studies on mental disorders in prisoners stated that 47% of male prisoners & 21% of female prisoners had anti-social personality disorder.108 According to an unsourced article in popular science magazine Scientific American, studies indicate that about 25% of prison inmates meet diagnostic criteria for psychopathy.9 A 2009 study of British prisoners found a prevalence for "categorically diagnosed psychopathy" of 7.7% in men & 1.9% in women.109

Homocides by psychopaths were almost always (93.3%) done in "cold blood" & premeditated in a 2002 study. For non-psychopaths the figure was 48.4% due to a much larger share of "crimes of passion".110

Despite having several characteristics that may seem useful to terrorists, there is little evidence that the majority of terrorists are psychopaths. Other characteristics such self-centeredness, unreliability, poor behavioral controls, & unusual behaviors may be disadvantages or make psychopaths unwilling to sacrifice themselves for a perceived higher cause.111 Indeed, the increased narcissism may produce the attitude that there is no higher cause than the pleasure of the psychopath.

A 2011 study of conditional releases for Canadian male federal offenders found that psychopathy was related to more violent & non-violent offences but not more sexual offences. For child molesters psychopathy was associated with more offences. Despite "their extensive criminal histories & high recidivism rate", psychopaths showed "a great proficiency in persuading parole boards to release them into the community." "High-psychopathy offenders (both sexual & non-sexual offenders) were about 2.5 times more likely to be granted conditional release than non-psychopathic offenders."112
edit Management
edit Clinical management

In practice, mental health professionals rarely treat psychopathic personality disorders as they are often considered untreatable & no interventions have proved to be effective. However, some of the difficulty has been attributed to the lack of clarity about the concept & diagnosis of psychopathy; the threat of danger to staff, or deceit or poor motivation from patients; & a lack of follow-up to test effectiveness. Despite pessimism, as of 1999, treatment of patients still takes place in a variety of psychiatric hospitals & secure units, & the research has indicated that some individuals do show some improvements when the right treatment is identified, & that longer periods of therapy often produce better results.113

It has been shown that punishment & behavior modification techniques do not improve the behavior of psychopaths. Psychopathic individuals have been regularly observed to become more cunning & better able to hide their behaviour. It has been suggested that traditional therapeutic approaches actually make psychopaths more adept at manipulating others & concealing their behavior. They are generally considered to be not only incurable but also untreatable.8

However, some researchers suggest that psychopaths can benefit as much as others from psychological treatment, at least in terms of criminal behaviors even if not on the central personality traits.9 For example, one therapeutic approach to juveniles reports reduced re-offending over a two year period compared to usual care.114
edit Legal response
edit United Kingdom

In the United Kingdom, "Psychopathic Disorder" was legally defined in the Mental Health Act (UK)115 as, "a persistent disorder or disability of mind (whether or not including significant impairment of intelligence) which results in abnormally aggressive or seriously irresponsible conduct on the part of the person concerned." This term, which did not equate to psychopathy, was intended to reflect the presence of a personality disorder, in terms of conditions for detention under the Mental Health Act 1983. With the subsequent amendments to the Mental Health Act 1983 within the Mental Health Act 2007, the term 'psychopathic disorder' has been abolished, with all conditions for detention (e.g. mental illness, personality disorder, etc.) now being contained within the generic term of 'mental disorder'.

In England & Wales, the diagnosis of dissocial personality disorder is grounds for detention in secure psychiatric hospitals under the Mental Health Act if they have committed serious crimes, but since such individuals are disruptive for other patients & not responsive to treatment this alternative to prison is not often used.116
edit United States

Psychopathy has quite separate legal & judicial definitions that should not be confused with the medical definition. The American Psychiatric Association is vigorously opposing any non-medical or legal definition of what purports to be a medical condition "without regard for scientific & clinical knowledge." 117 Various states & nations have at various times enacted laws specific to dealing with psychopaths.

In the United States, approximately 20 states currently have provisions for the involuntary civil commitment for sex offenders or sexual predators, under Sexually violent predator acts, avoiding the use of the term "psychopath." These statutes & provisions are controversial & are being reviewed by the U.S. Supreme Court as a violation of a person's Fourteenth Amendment rights.118 (See Foucha v. Louisiana for an example.119)

Washington

Washington State Legislature 120 defines a "Psychopathic personality" to mean "the existence in any person of such hereditary, congenital or acquired condition affecting the emotional or volitional rather than the intellectual field & manifested by anomalies of such character as to render satisfactory social adjustment of such person difficult or impossible."118 The same statute defines the "sexual psychopath" as "any person who is affected in a form of psychoneurosis or in a form of psychopathic personality, which form predisposes such person to the commission of sexual offenses in a degree constituting him a menace to the health or safety of others" for prison sentencing purposes in the Sentencing Reform Act of 1981.120

California

California enacted a psychopathic offender law in 1939, since greatly outmoded & revised,121 that defined a psychopath solely in terms of offenders with a predisposition "to the commission of sexual offenses against children." A 1941 law122 attempted to further clarify this to the point where anyone examined & found to be psychopathic was to be committed to a state hospital & anyone else was to be sentenced by the courts. However, these laws were enacted years before the American Psychiatric Association began publishing the Diagnostic & Statistical Manual of Mental Disorders which is used today for diagnosis & does not include "psychopathic offender". Hence, these laws are of historical interest only.

 
Develop by SEO Booster Tips | Estates For Sales | Expert Zone